Formulation Strategies for Nose-to-Brain Drug Delivery

Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of Blood-Brain barrier other limitations oral routes administration makes drug delivery brain somewhat tricky. As a result, numerous novel systems being developed for brain. However, nose-to-brain is one most effective, safe, non-invasive methods. Purpose: To discuss system in treatment various provide information about formulation strategies designed deliver effectively. Methods: A preliminary search was conducted PubMed, OVID Medline, Embase, ScienceDirect, Web Science, Google Scholar databases using keywords “Intranasal delivery, transport, formulations intranasal delivery.” Results: Various marketed listed this review, like naringenin, donepezil, pentamidine, rivastigmine, efavirenz, desvenlafaxine, lamotrigine, haloperidol, nimodipine, olanzapine, valproic acid, ovalbumin, clonazepam, fentanyl citrate, nifedipine form poloxamer chitosan-based nano-formulation, nano-emulsion, chitosan niosomes, containing emulsion, solid-lipid nanoparticles, PLGA-chitosan solution, mucoadhesive microemulsion, nanostructured lipid carriers, cationic liposomes, peptide-attached multimellar liposomes with their research findings treating disorders. Conclusion: This review discusses processes, pathway its action, advantages over routes, barriers system, current transport.